Dopamine and Serotonin “hydrochloride”

    Most people know about Dopamine and Serotonin. These are the neurotransmitters flowing through our body that regulate things such as mood, motivation, focus, sociability and empathy. Low levels of these neurotransmitters leads to increased anxiety and depression. This is why things like MDMA or cocaine will induce a comedown, because the excessive rush is followed by a temporary period of depletion. Did you know however, that these chemicals are not exclusive to the human body and powdered dopamine and serotonin (hydrochloride salts) can be synthesized and sold? The use cases for dopamine and serotonin hydrochloride are not what you would think, though.

Reddit user discussion from thread “Dopamine HCL powder” by /u/Double_Melt

What’s the Deal?

    The thing that causes psychoactive drugs to “work” is that the chemical crosses the “blood brain barrier” upon entering the body, and therefore it physically makes it’s way inside our central nervous system (responsible for all of our sensory perception). When dopamine and serotonin exist outside of our body, it can’t really just enter the body and take the place you would expect it to go. In order for these chemicals to take a powder form, they must exist as a hydrochloride salt.

    Dopamine hydrochloride does have some medical use, but not for anything you would expect. Serotonin hydrochloride is a very obscure chemical, and almost no information exists on the internet about it’s use. With that being said, DrugBank does suggest it has some potential as a psychoactive agent. Dopamine and serotonin hydrochloride are more or less irrelevant to common folk, in other words.

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Dopamine and Serotonin Hydrochloride Suppliers

Image of Serotonin hydrochloride listing
Image of Dopamine hydrochloride listing

“For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.”

Description of Serotonin hydrochloride from DrugBank

“Dopamine HCl (Hydrochloride) is indicated for the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure.

Patients most likely to respond adequately to dodpamine HCl are those in whom physiological parameters, such as urine flow, myocardial function, and blood pressure, have not undergone profound deterioration. Multiclinic trials indicate that the shorter the time interval between onset of signs and symptoms and initiation of therapy with volume correction and dopamine HCl, the better the prognosis. Where appropriate, blood volume restoration with a suitable plasma expander or whole blood should be accomplished or completed prior to administration of dopamine HCl.”

Indications (medicinal uses) of Dopamine hydrochloride, from RxList.com

Alternatives to Dopamine and Serotonin Hydrochloride

    Anyone can find several suppliers of both chemicals across the internet, but given that they are essentially useless for what we all thought, what are our options?

L-Tyrosine: Precursor chemical to dopamine, exists in the brain and actively turns into dopamine. L-Tyrosine is available widely as a supplement and there is evidence that it crosses the blood-brain barrier when consumed. Anecdotally, users report stimulation and elevated mood.

5-HTP: 5-Hydroxytryptophan is the precursor chemical to serotonin (which is technically 5-Hydroxytryptamine). Also a widely available supplement, it definitely does cross the blood-brain barrier to some degree and has huge popularity as an anti-depressant. Many MDMA users also tout it as a “comedown tool” to replenish serotonin levels. DO NOT take this one if you are taking anti-depressants (SSRI’s) already, as you can induce serotonin syndrome on yourself.

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