What’s the Catch with “Zopiclone Impurity 22”?

    “Zopiclone Impurity 22” is the official identifier for a virtually unknown chemical that has never been studied or marketed as a drug. It’s molecular formula is C17H17BrN6O3, while the formula for Zopiclone is C17H17ClN6O3. Eszopiclone and Zopiclone share the same formula but differ structurally by a single bonding point. The main difference seen in “Zopiclone Impurity 22” is that a single Chlorine atom is replaced with Bromine.

    Although a small change to a chemical can sometimes drastically change it’s properties, it seems as if the pharmacological action of this chemical is almost the same as it’s parent. 


The Result

    While it was available, the U-Dream brand was selling one of the most popular and demanded sleep products you can buy in Canada. Reviews of it tout it constantly as being the best thing you can buy for sleep. Some anecdotes describe absolutely desperate users had tried countless products (including prescription drugs) and had no success until they found U-Dream.

In the first review seen on this list from, one user foreshadows the news about the U-Dream Herbal product but believes it to be caused by the plethora of “adaptogen” agents.

    The U-Dream website now contains an official statement on the news. They address the product being made illegal overnight Canada-wide, and deny the intentional addition of “Zopiclone Impurity 22”. They state that they are eager to get their product back on the market and are cooperating with Health Canada to the fullest. One has to wonder if the new version of the product will be even a tenth as effective without the magic Zopiclone-like ingredient.

Official ingredient list for “U-Dream Herbal” sleep aid, as found on their website.
The website also contains a heavily cautioning disclaimer about the way to use the product. They warn strongly against mixing it with other depressants and using it for longer than a very brief period. These types of cautions are somewhat unusual for the benign products “U-Dream Herbal” is made up of, and are more indicative of the intentional presence of “Zopiclone Impurity 22”.

Read More about “Zopiclone Impurity 22”:

About Zopiclone Impurity 22 – Zodiac Life Sciences

About Zopiclone Impurity 22 – CYMIT QUÍMICA

“Zopiclone Impurity 22” – discussion on /r/researchchemicals

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